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It concludes, "the average acre planted to glyphosate-tolerant crops is requiring more and more help from other herbicides, a trend with serious environmental and economic implications" [http://www.biotech-info.net/Full_version_first_nine.pdf].
This is not to mention the fact that most people who aware of the issue are not comfortable with herbicides/pesticides on their food in the first place, let alone in increasing amounts. And this upward spiral in resistance/usage can be expected to continue. A related issue is the growing resistance of insects to GM Bt crops [http://www.ndtv.com/template/template.asp?category=National&template=Farmerssuicide&slug=Farmers%20hit%20by%20failed%20Bt%20cotton%20crop%20in%20AP&id=84101&callid=1] [http://www.newscientist.com/article.ns?id=dn2340&lpos=related_article1] [http://www.biotech-info.net/changes_in_refuge.html] [http://www.biotech-info.net/wrangling.html]. See also [http://www.grain.org/research/btcotton.cfm?id=302 BT Cotton in Andhra Pradesh - A Three Year Assessment] [http://www.ddsindia.com/www/PDF/BT_Cotton_-_A_three_year_report.pdf]
If all this weren't enough, exposure to glyphosate (the active ingredient in Roundup) increases the risk of non-Hodgkin's lymphoma and other serious health concerns. [http://www.mindfully.org/Pesticide/Non-Hodgkin-Lymphoma-Pesticides.htm] [http://stanley.niehs.nih.gov/ehp/query.html?col=ehp&qt=%2Bkeywords%3Aglyphosate%2C+-url%3Aabs.html+-url%3A-abs.html+-url%3A.pdf+-url%3Aabstract&charset=iso-8859-1&qp=url%3Ahttp%3A%2F%2Fehpnet1.niehs.nih.gov%2F+url%3Ahttp%3A%2F%2Fehp.niehs.nih.gov%2F+url%3Ahttp%3A%2F%2Fehis.niehs.nih.gov%2F+url%3Ahttp%3A%2F%2Fehpnet2.niehs.nih.gov%2F&qc=ehp]. See also [http://www.organicconsumers.org/Monsanto/heavyuse32905.cfm] [http://www.pesticide.org/gly.pdf] [http://www.organicconsumers.org/monsanto/pregnancy060305.cfm]. Additionally, as with other herbicides such as Atrazine, the use of Roundup has been linked to the decimation of frogs worldwide [http://www.umc.pitt.edu:591/m/FMPro?-db=ma&-lay=a&-format=d.html&id=2115&-Find]. This is truly unfortunate as it is estimated that a single frog can consume 10,000 garden/farm pests in a growing season [http://highered.mcgraw-hill.com/sites/0072909498/student_view0/biological_controls.html].