O'Keefe helped launch the [[American Majority]] Tea Party group which trains right-wing candidates to run for office. He sat on the Board of Directors and was the Chairman of [[Club for Growth]] Wisconsin, which ran divisive ads in support of Governor Scott Walker's radical overhaul of collective bargaining rights for Wisconsin workers. <ref name="WPRecall">Marc Fisher, [http://www.washingtonpost.com/politics/wisconsin-gov-scott-walkers-recall-sharpens-fight-over-money-in-politics/2012/03/22/gIQAbUHDaS_story_1.html Wisconsin Gov. Scott Walker’s recall: Big money fuels small-government fight], ''Washington Post'', Mar 25, 2012</ref>
He also helped found the [[Center for Competitive Politics]], a legal organization that criticizes opposes campaign finance regulations, taxpayer-financed political campaigns, as well as provides pro bono legal services for lawsuits questioning the constitutionality of election statutes.<ref name="WSJ"/></ref>
O'Keefe was also co-founder of the [[Campaign for Primary Accountability]], a super PAC funding opposition to incumbent members of Congress.<ref name="WPRecall"/><ref>Paul Kane, [http://www.washingtonpost.com/politics/one-super-pac-takes-aim-at-incumbents-of-any-party/2012/03/07/gIQAhOfwxR_story.html One super PAC takes aim at incumbents of any party], ''Washington Post'', Mar. 7, 2012</ref>