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SW: SW: →Safety Testing of AquAdvantage Salmon: add hormone stuff
==== FDA Conclusion ====
The FDA concluded as follows: "We found no clinically relevant differences in the serum chemistry or hematology values for AquAdvantage Salmon compared with contemporaneous non-GE Atlantic salmon that are clearly attributable to the GE construct."
=== Hormone Testing ===
In a 2004, AquaBounty Technologies tested the muscle and skin of diploid and triploid control (non-GE) and GE salmon for the following: growth hormone (GH) and insulin like growth factor 1 (IGF1), estradiol, testosterone, T3, T4, and 11-ketotestosterone. The tests were performed on a total of 73 fish (43 control and 30 GE salmon). The test's detection limit for growth hormone was 6.24 ng/g. All of the fish tested below the detection limit for growth hormone. From this data (or lack thereof), the FDA concluded "No differences were observed in levels of growth hormone in edible tissues at the level of quantitation for the analytical method." Michael Hansen compares this to a cop using a radar gun that cannot detect speeds below 110mph to compare a car going 30mph and one going 90mph determining that there was no detectable difference in the speeds of the cars.<ref>Jill Richardson, Phone interview with Michael Hansen, September 7, 2010.</ref> No differences in levels of growth hormone were observed because no growth hormone was observed at all.
Growth hormone levels are linked to levels if IGF1. Only six GE salmon and 11 non-GE salmon had levels of IGF1 above the detection limit of 2.18ng/g (parts per billion). The GE salmon had a mean of 10.26ng/g with a standard deviation of 4.971ng/g, a minimum of 3.97ng/g, and a maximum of 18.43ng/g for IGF1. The non-GE salmon had a mean of 7.34ng/g, a standard deviation of 2.818ng/g, a minimum of 3.56ng/g, and a maximum of 12.24 for IGF1.
The document noted that "initial evaluation of the results suggested that there may have been an increase in the
level of IGF1 in the GE fish compared to sponsor control fish" but then dismissed the differences as only existing between diploid GE and non-GE fish. All six GE salmon that tested above the detection limit for IGF1 were diploids. Additionally, seven control salmon that tested above the detection limit were diploids. A comparison of the data for GE and non-GE diploids shows that "mean IGF1 level for the GE and non-GE salmon, the range of values for the GE salmon exceeded that of the non-GE salmon by more than 10%." As the document notes "It <nowiki>[IGF1]</nowiki> has been considered as a potential hazard for human consumption following increased growth hormone levels in food producing animals."
=== Allergenicity ===
